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KMID : 0363320060270030715
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 3 p.715 ~ p.724
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Effects of Commiphora Myrrha (CM) on the Monosodium Urate (MSU)-induced Gout Model in Rats
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Jung Dae-Ho
Chang Sun-Kyu
Cho Chung-Sik
Kim Cheol-Jung
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Abstract
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Objective : To identify the inhibitory effects of Commiphora Myrrha (CM) on monosodium urate (MSU)-induced gout model in rats.
Materials and Methods: After pretreatment with CM-I (125mg/kg) or CM-II (50mg/kg) for 7 days followed by ones injection of MSU solution. the various indicators related to gout were measured on hematological and serum level including joint inflammation, Also, it was studied whether FBM directly inhibits the activity of xanthine oxidase in vitro.
Results : As a result of this study, CM didn’t show cytotoxicity in Jurkat cells, but it showed significant inhibition of activity of xanthine oxidase in vitro. CM slightly inhibited joint inflammation induced by MSU though not with statistical significance. CM partially decreased MSU-induced albumin, globulin, AST, ALT, BUN, creatinine. WBC, platelet count and ESR level and significantly decreased MSU-induced uric acid in serum.
Conclusion : These results suggest that CM has therapeutic effects that are applicable to prevention and treatment of gout, and should be further investigated.
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KEYWORD
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Gout, Commiphora Myrrha(CM), Monosodium Urate(MSU), xanthine oxidase(XO)
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